(Image: Zephyris (Richard Wheeler) as part of the English languege Wikipedia) |
Sixty years ago, on April 25, 1953, American biologist James Watson (b. April 26, 1928) and English physicist Francis Crick (1916-2004) formally announced they had discovered “the secret of life”— the double helix that forms DNA, the molecule containing the genetic instructions for all living organisms. They published their findings in the scientific journal “Nature.”
What is likely one of the first written records of the discovery was just auctioned for $6 million: a letter from Francis Crick to his 12-year-old son, who was away at boarding school. The seven-page letter dated March 19, 1953 explains in detail the double-helix structure of DNA, complete with illustrations.
Although Watson and Crick are credited with this discovery, their research stands on the shoulders of others who came before them as well as contemporaries who contributed to their understanding.
Johannes Friedrich Miescher. Wikipedia |
Although he published his findings, the significance of his discovery wasn’t appreciated until about 50 years later, after his death.
Albrecht Kossel. Wikipedia |
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Phoebus Levene. Wikipedia |
Levene is known for his tetranucleotide hypothesis, which proposed that DNA was composed of equal parts adenine, guanine, cytosine and thymine. However, later research showed this model to be too simplistic.
Erwin Chargaff. NIH |
Chargaff’s second rule was that the composition of DNA varied from species to species, meaning that DNA was likely the carrier of the genetic material, not the protein found in cells, as was thought at the time.
Maurice Wilkins. Wikipedia |
Rosalind Franklin. Wikipedia |
Ten years ago, the Human Genome Project was completed. The purpose of the 13-year project, coordinated by the U.S. Department of Energy and the National Institutes of Health, was to identify the 20,000-plus genes in human DNA and determine the sequences of the three billion chemical base pairs that make up human DNA.
Last year another milestone was reached: the initial results of the Encyclopedia of DNA Elements (ENCODE) project, launched in 2003, were released in a series of 30 papers published in multiple journals, including Nature, Genome Research, and Genome Biology. The goal of the ENCODE project is to identify all functional elements in the human genome.
As DNA research becomes even more complex, it’s fitting to take a look back at, and honor, the original genetic scientists. Although most of the original genetic researchers have died, James Watson, at 85, still lives to see the scientific breakthroughs that have been made as a result of his discovery.
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