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sábado, 15 de marzo de 2014

Health Food for Foodies

Chefs and doctors are teaming up to create healthy dishes you might actually crave

Chef and restaurateur David Bouley harnesses his French culinary background combined with the wisdom of naturopathy and medicine to create dishes infused with nutrient-rich plants grown at his restaurant Bouley Botanical.

THIS WEEKEND, David Eisenberg, a physician, will talk shop with some 450 colleagues, from ophthalmologists to endocrinologists. Instead of wearing a white coat in a medical lab at the Harvard School of Public Health, however, he'll don a white apron in a teaching kitchen at the Culinary Institute of America (CIA) in Napa Valley, Calif.

A Delicious Prescription F. Martin Ramin/The Wall Street Journal, Styling by Anne Cardenas

They're coming together for the 10th meeting of the Healthy Kitchens/Healthy Lives conference. It's a joint project of the CIA, Harvard School of Public Health and Samueli Institute, a non-profit dedicated to investigating healing practices. The conference brings doctors, registered dietitians and nutritionists, educators, sustainability experts and healthcare professionals together with chefs, such as Mollie Katzen and Michelin-starred Suvir Saran.

Dr. Eisenberg co-founded the program as "a place where nutrition scientists could teach medical providers what they need to know about which foods we should eat more of, or less of, and why," he said. "And, based on scientific evidence, chefs [translate] that into demonstrations on how to prepare healthy, delicious, affordable, easy-to-make dishes." For him, the continuity between food and medicine is obvious and practical. "It is not my view that the right question is 'How do we replace drugs with foods?' The premise of this conference is 'How do we help people move in the direction of a healthier lifestyle and diet, to prevent illness or manage illness that's already occurred?'"

Though connecting food and health has a long history, this collaboration between doctors and chefs represents a newer approach—studying and sharing how certain foods can prevent diseases or help manage them. In May, the Goldring Center for Culinary Medicine at Tulane University will debut the nation's first teaching kitchen affiliated with a medical school. Located in New Orleans, it will be a place for students, doctors, chefs and the local community to investigate the role food can play in managing obesity and related diseases.

Interactive: Culinary Rx

F. Martin Ramin/ The Wall Street Journal, Styling by Anne Cardenas

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The Goldring Center's Executive Director and Assistant Dean for Clinical Services, Timothy Harlan, is both a chef and a doctor, having owned restaurants before attending medical school. He said the program's goal is to school doctors-in-training in "some very simple techniques they can use to change the dialogue with their patients, change the way their patients think about food and nutrition." Classes integrate nutrition with biochemistry, physiology and anatomy. The program also encompasses a food-research branch and has licensed its curriculum to two other medical schools. Dr. Harlan added, "Make no mistake, I am an allopathic physician. I do not believe in anything other than evidence-based medicine. As an internist, I prescribe statins and beta-blockers and ACE inhibitors and aspirin. I believe in them and they have a role. Diet alone is very good. Medication alone is very good. But diet plus medication is synergistic. It's another tool in the box that physicians should have available to them."


Danny Kim for The Wall Street Journal

Culinary Rx

Both the Harvard/CIA partnership and the Goldring Center's programming rely heavily on the principles of the Mediterranean diet, which emphasizes fruits and vegetables, whole grains, legumes, healthy fats, certain fish and a minimal quantity of good-quality meat and cultured dairy. The results of a recent study by the Harvard School of Public Health and Cambridge Health Alliance link the diet with lower risk of heart disease. A previous study, published by the Journal of the American College of Cardiology, shows that the Mediterranean diet is linked with lower risk of obesity, diabetes and cancer.

The chefs involved are eager to demonstrate that eating for wellness needn't mean dull "health food." David Bouley, for one, grew up in a French family "where the pantry and medicine cabinet always seemed to overlap," he said. He recently opened Bouley Botanical, an event space and "living pantry" growing 400 plant species to provision Mr. Bouley's Manhattan restaurants.

Plants growing by the window at Bouley Botanical Danny Kim for The Wall Street Journal

A continuing interest in the healing properties of food had caused Mr. Bouley to seek the advice of nutritionists in the past. "All they ever told me was what not to put in food," Mr. Bouley said. "They never told me what I should cook." It wasn't until he began to collaborate with a medical doctor, Mark Hyman, that the chef found what he was looking for.

During last fall's New York City Wine & Food Festival, Dr. Hyman, author of "The Blood Sugar Solution" (Little, Brown), teamed up with Mr. Bouley for a dinner called "The Chef and the Doctor." Over the meal, the two discussed the healing properties of ingredients such as mushrooms (full of polysaccharides, said to battle tumors) and sardines (omega-3s, believed to protect against heart disease and stroke). Some dishes they collaborated on

  • a creamy almond soup sharpened by glazed scallions; 
  • wild mushrooms with white truffle, sweet garlic, grilled toro and 
  • coconut foam—are now staples on the menu at Bouley restaurant.
“'All they ever told me was what not to put in food. They never told me what I should cook.'”

Another high-profile New York chef, Seamus Mullen, has been working in an idiom he calls "Hero Food," in a cookbook of the same name and at his acclaimed restaurant Tertulia. Mr. Mullen has seen for himself what diet can do: According to his doctor, Frank Lipman, he has reversed the effects of rheumatoid arthritis by eating the right foods. Mr. Mullen's pain was debilitating; he endured multiple hospitalizations. "I knew there was a direct correlation between food and my body's ability to deal with inflammation," he said. "But I wasn't sure how to put that into practice." It took months, but when Mr. Mullen woke up one morning last May without chronic pain, his life changed. He started cycling again (he was once semi-pro). Last October, he said, for the first time his blood-test results showed no sign of rheumatoid arthritis.

Mr. Mullen believes eliminating gluten was a major factor, in addition to sticking to "hero foods" like leafy greens, grass-fed meat and eggs. (For more on the benefits associated with these foods, see "Culinary Rx.") "The fundamental part of the equation is that it needs to be delicious, that the ingredients are well sourced," he said. "I take it one step further by increasing the good fats and cutting back on some of the carbohydrates and sugar." Take a recipe from Mr. Mullen's book, tosta matrimonio: grilled flatbread topped with tomatoes and anchovies, their briny tang tempered by fresh ricotta and a drizzle of saba, a naturally sweet grape-juice reduction. The dish packs a big dose of heart-disease-fighting omega-3s from the fish; cancer-battling folate and sulfur from garlic; and anti-inflammatory olive oil. Mr. Mullen hopes to collaborate further with Dr. Lipman on a restaurant concept.

GREEN SPACE | Planters at Bouley Botanical supply produce to chef David Bouley's Manhattan restaurants. Danny Kim for The Wall Street Journal

Beyond the rise in, and growing concern about, rates of heart disease, obesity and diabetes, the conversation around the Affordable Care Act is shaping thinking about food as prevention. "It's pretty clear that if we can reduce the burden of disease, we can reduce the burden of the cost of disease," said Dr. Harlan of the Goldring Center. "Farm before pharm" is the mantra of a number of programs designed to provide assistance to children at risk of developing diet-related diseases. In this vein, Wholesome Wave, a non-profit whose mission is to make locally grown produce available to people at all income levels, launched its Fruit and Vegetable Prescription Program (FVRx) in 2010.

Now available in six states, FVRx prescriptions are dispensed by primary care providers and redeemed at farmers' markets. According to a 2012 study by the program's healthcare partners, 37.8% of participants decreased their BMI (body mass index, a weight-to-height calculation used to predict health problems) over one year. Wholesome Wave President and CEO Michel Nischan—a chef, restaurateur and cookbook author—points to affordable local food access as a platform for policy change. "If large employers could see an investment in providing minimum-wage employees a connection with a company doctor and an opportunity to increase fruit and vegetable consumption, their premiums are going to go down pretty significantly on the back end," he said.

It is the goal of Mr. Nischan and other chefs collaborating with doctors and farmers to advocate for the role that nutrition can play in overall wellness by gathering and offering up data that supports their claims. Encouraging people to eat more of these foods—by showing how delicious they can be—is the first step.

By KATHLEEN SQUIRES
March 14, 2014

domingo, 19 de enero de 2014

Real King Kong may have been brought down by fruit


The extinction of Gigantopithecus has been blamed on switching to a fruit-filled diet (Image: Natural History Museum, London/Science Photo Library)

It was fruit killed the beast. Gigantopithecus, the largest known ape, may have been wiped out by a diet of fruit containing little nourishment.

Nearly 80 years ago, Dutch anthropologist Gustav Heinrich Ralph von Koenigswald discovered a giant human-like tooth in a drug store in Hong Kong, and named the animal it came from Gigantopithecus.

Since then, thousands more large teeth – and three jawbones – have come to light in southern Asia. They show that Gigantopithecus stood up to 3 metres tall, making it the largest known ape, and was probably related to orang-utans. But why it went extinct remains unclear.

Now Yingqi Zhang of the Chinese Academy of Sciences's Key Laboratory of Evolutionary Systematics of Vertebrates in Beijing has analysed 17 newly discovered Gigantopithecus teeth. At less than 400,000 years old, they are among the youngest remains of the ape ever found, meaning they belonged to some of the last of the giant apes to walk the Earth.

Poor dental hygiene

Many of the teeth were eroded. This poor dental hygiene hints at a problem with their diet, says Zhang. "There was something wrong before Gigantopithecus's extinction, and I think it comes from the food."

The ape may have had to switch diet as the climate cooled and its preferred food – probably plants like bamboo – became rare. The teeth suggest it turned to less-nutritious fruit rich in enamel-eroding acids, says Zhang.

But fruit is good for most apes, says Kornelius Kupczik of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. "Chimpanzees eat a lot of fruits that are extremely bitter or acidic to the human palate," he says, yet their teeth don't rot much.

Journal reference: Quaternary International, DOI: 10.1016/j.quaint.2013.12.008


ORIGINAL: New Scientist
14 January 2014

domingo, 26 de mayo de 2013

Conozca la 'kriptonita' contra el cáncer

ORIGINAL: Semana
24 mayo 2013

Las células cancerígenas podrían ser 'reeducadas' gracias a un componente de la dieta mediterránea.
La apigenina está en el perejil, el apio y la manzanilla, entre otras frutas y vegetales.
Investigadores de la Universidad de Ohio, en Estados Unidos, descubrieron que esta especie de "kriptonita" llamada apigenina -presente en el perejil, el apio y la manzanilla, entre otras frutas y vegetales- debilita las células del cáncer.

Al alterar un paso específico en la regulación del gen, este compuesto reeduca las células cancerígenas en células normales que eventualmente mueren.

"Creo que lo más importante de nuestro trabajo es que a diferencia de un fármaco, los compuestos que están en una dieta ayudan a restablecer un balance en la célula dirigiéndose a muchos compuestos celulares", explicó Andrea Doseff, codirectora del estudio.

El equipo pudo identificar 160 moléculas dentro de una célula humana asociadas a la apigenina. Esto permite, según el estudio publicado en la revista especializada Proceedings of the National Academy of Sciences (PNAS), restablecer un balance que hace que una célula cancerígena sea susceptible a fármacos que posiblemente antes no podían ser efectivos.


Buenas y malas Este hallazgo representa un avance en lo que sabemos sobre los beneficios de los micronutrientes, pues mucho de lo que se conoce hasta ahora está basado en estudios epidemiológicos que muestran una relación positiva entre ingerir comidas específicas y una vida más saludable.

La apigenina afecta a un repertorio de proteínas de una célula humana y las hace más accesibles. "Lo que no se sabía hasta ahora es que un compuesto en una comida puede cambiar qué tipo de proteínas expresamos en una célula".

"Tienes proteínas que pueden estar en una forma buena, y las mismas proteínas pueden tener diferencias que la hacen malas. Lo que descubrimos es que esta apigenina se une a la ribonucleoproteína y cambia el repertorio de las proteínas, convirtiendo a una célula con repertorios cancerígenos a lucir como una célula con repertorios no cancerígenos", explicó Doseff.

La experta aclara que su estudio de laboratorio no quiere decir que con comer apio o perejil se pueden matar a las células cancerígenas.

"Lo que nos permite es cambiar la forma en la que pensamos los compuestos de las comidas y sus diferencias con un fármaco", agrega.

Súper compuesto

El equipo de Doseff decidió investigar este compuesto porque sabían que era un potente antiinflamatorio y anteriormente habían determinado sus beneficios para las leucemias.

"La ventaja es que este compuesto ya está presente en dietas que la gente está comiendo mucho porque tiene beneficios cardiovasculares", explica la especialista.

A partir de esta investigación, expertos podrían determinar cómo se pueden modificar las comidas de una manera funcional para poder incrementar la cantidad de apigenina accesible para nuestro cuerpo.

"¿Cómo hacemos para que algo que sabemos que es bueno lo podamos tener en una cantidad que realmente llegue grado de hacerlo eficaz para nuestra salud?", se pregunta la especialista.

Los suplementos podrían ser una manera, aunque cabría determinar si se metaboliza de la misma forma que un alimento.

La investigadora explica que en la nutrición hay un balance, por lo que "la apigenina es una criptonita que necesita nuevas criptonitas que están por descubrirse".

Doseff considera que al saber cómo actúan los compuestos, se puede acelerar la implementación de mejores terapias y realizar una intervención preventiva.

COMENTARIO:
Señores Semana les falto colocar que en el grupo de investigación esta un Colombiano. Daniel Arango. 
http://researchnews.osu.edu/archive/apigenin.htm

jueves, 26 de enero de 2012

CoLab climático: El aprovechamiento de la mente colectiva para mitigar el cambio climático

ORIGINAL: FastCoexist

Image: Iakov Filimonov/Shutterstock
Ciertamente, no parece que nadie a su cargo tiene alguna idea sobre cómo detener el cambio climático, así que vamos a abrirnos a todo el mundo. Un proyecto de crowdsourcing del MIT ha encontrado las mejores soluciones que provienen del resto de nosotros - como medios de transporte personal rápidos o convencernos a todos a comer menos carne.

A la vista de la crisis planetaria, no deben ser descartada ninguna opinión, no se sabe quién podría llegar a la próxima gran idea. Esto es especialmente cierto con el cambio climático - un dilema que tiene pocas respuestas definitivas.

En 2010, el Colab Climático MIT - el brazo de crowdsourcing sobre clima del Centro para la Inteligencia Colectiva de MIT - trató de aplicar crowdsourcing al próximo acuerdo internacional sobre el clima, con las ideas arriba presentadas a las Naciones Unidas, el Congreso y el Departamento de Energía. Aunque las ideas aportadas nunca han contribuído a un acuerdo importante sobre cambio climático, el CoLab de clima está de vuelta otra vez con sus 2.011 ganadores del concurso. En esta ocasión, los participantes se les dio una tarea diferente: descubrir cómo la economía del siglo 21 debe evolucionar para responder a los riesgos del cambio climático. Nuestros equipos favoritos ganar, todos los cuales llegarán a presentar sus ideas ante las Naciones Unidas y el Congreso a finales de este mes, están a continuación.

REDUCIR EL CONSUMO DE CARNE DE MUNDIAL

Propuesto por un equipo afiliado con el blog liberal Daily Kos, la idea ganadora sugiere reducir el consumo de carne para aliviar nuestra carga del planeta. El equipo trabaja a través de estadísticas contundentes: Se estima que

  • el 80% a 90% de los terrenos despejados en el Amazonas brasileño se puede atribuir a los pastos o la ganadería, 
  • la deforestación en los trópicos representa hasta un 20% de las emisiones de CO2 de la actividad humana, y 
  • el aumento de ganado y aves de corral es responsable del 51% de las emisiones de gases de efecto invernadero (en parte porque el metano es liberado a partir de gases digestivos de los animales).
Esto no quiere decir que todos deben dejar de comer carne hoy en día. El equipo propone "una rápida aceleración de la educación a través de las organizaciones existentes, con énfasis en las instituciones más grandes y con más énfasis en las crecientes economías de China e India", así como el aumento de presión "por la influencia de la Ley Agrícola de EE.UU. de 2012, para tratar de reducir los subsidios del gobierno de EE.UU. para el maíz y la soja, que contribuyen a la cultura de la fábrica de ganado. " No hay necesidad de eliminar la carne por completo, simplemente que lo disminuyamos como un alimento básico diario puede hacer una gran diferencia en las emisiones de gases de efecto invernadero.

PERSONAL REDES Rapid Transit

Christopher Fry, un investigador del Media Lab del MIT, propone la instalación generalizada de un sistema personal de tránsito rápido (PRT) en las áreas urbanas y suburbanas más densas que contienen el 50% de la población de EE.UU.. Fry dice: "Podemos eliminar los coches, autobuses, metros y aviones de corto alcance de nuestras áreas urbanas con una malla de células de 1 milla cuadrada de mag-lev guías, 20 pies por encima de una ciudad en la que módulos para dos personas están a la espera para los clientes a una distancia media de 1 / 4 milla de cada punto de la red. Estos módulos utilizarán menos energía y dinero por pasajero por milla que cualquier otro coche eléctrico práctico, autobús o tren (ligero o no) y son más seguros y más rápidos. "

El PRT ya existe. La NASA, por ejemplo, está probando actualmente SkyTran, un sistema de móculos para dos personas pendientes de guías sobre las calles y carreteras. Los módulos pueden parar cada media milla más o menos para cualquiera que necesite bajar.