Mostrando entradas con la etiqueta Imperial College London. Mostrar todas las entradas
Mostrando entradas con la etiqueta Imperial College London. Mostrar todas las entradas

martes, 15 de septiembre de 2015

Deep Learning Machine Teaches Itself Chess in 72 Hours, Plays at International Master Level

In a world first, an artificial intelligence machine plays chess by evaluating the board rather than using brute force to work out every possible move.

It’s been almost 20 years since IBM’s Deep Blue supercomputer beat the reigning world chess champion, Gary Kasparov, for the first time under standard tournament rules. Since then, chess-playing computers have become significantly stronger, leaving the best humans little chance even against a modern chess engine running on a smartphone.

But while computers have become faster, the way chess engines work has not changed. Their power relies on brute force, the process of searching through all possible future moves to find the best next one.

Of course, no human can match that or come anywhere close. While Deep Blue was searching some 200 million positions per second, Kasparov was probably searching no more than five a second. And yet he played at essentially the same level. Clearly, humans have a trick up their sleeve that computers have yet to master.

This trick is in evaluating chess positions and narrowing down the most profitable avenues of search. That dramatically simplifies the computational task because it prunes the tree of all possible moves to just a few branches.

Computers have never been good at this, but today that changes thanks to the work of Matthew Lai at Imperial College London. Lai has created an artificial intelligence machine called Giraffe that has taught itself to play chess by evaluating positions much more like humans and in an entirely different way to conventional chess engines.

Straight out of the box, the new machine plays at the same level as the best conventional chess engines, many of which have been fine-tuned over many years. On a human level, it is equivalent to FIDE International Master status, placing it within the top 2.2 percent of tournament chess players.

The technology behind Lai’s new machine is a neural network. This is a way of processing information inspired by the human brain. It consists of several layers of nodes that are connected in a way that change as the system is trained. This training process uses lots of examples to fine-tune the connections so that the network produces a specific output given a certain input, to recognize the presence of face in a picture, for example.

In the last few years, neural networks have become hugely powerful thanks to two advances.
  1. The first is a better understanding of how to fine-tune these networks as they learn, thanks in part to much faster computers. 
  2. The second is the availability of massive annotated datasets to train the networks.
That has allowed coicts the best move 46 percent of the time and places the best move in its top three ranking, 70 percent of the time. So the computer doesn’t have to bother with the other moves.

That’s interesting work that represents a major change in the way chess engines work. It is not perfect, of course. One disadvantage of Giraffe is that neural networks are much slower than other types of data processing. Lai says Giraffe takes about 10 times longer than a conventional chess engine to search the same number of positions.

But even with this disadvantage, it is competitive. “Giraffe is able to play at the level of an FIDE International Master on a modern mainstream PC,” says Lai. By comparison, the top engines play at super-Grandmaster level.

That’s still impressive. “Unlike most chess engines in existence today, Giraffe derives its playing strength not from being able to see very far ahead, but from being able to evaluate tricky positions accurately, and understanding complicated positional concepts that are intuitive to humans, but have been elusive to chess engines for a long time,” says Lai. “This is especially important in the opening and end game phases, where it plays exceptionally well.

And this is only the start. Lai says it should be straightforward to apply the same approach to other games. One that stands out is the traditional Chinese game of Go, where humans still hold an impressive advantage over their silicon competitors. Perhaps Lai could have a crack at that next.

Ref: arxiv.org/abs/1509.01549 : Giraffe: Using Deep Reinforcement Learning to Play Chess

mputer scientists to train much bigger networks organized into many layers. These so-called deep neural networks have become hugely powerful and now routinely outperform humans in pattern recognition tasks such as face recognition and handwriting recognition.

So it’s no surprise that deep neural networks ought to be able to spot patterns in chess and that’s exactly the approach Lai has taken. His network consists of four layers that together examine each position on the board in three different ways.

  1. The first looks at the global state of the game, such as the number and type of pieces on each side, which side is to move, castling rights and so on. 
  2. The second looks at piece-centric features such as the location of each piece on each side, while 
  3. the final aspect is to map the squares that each piece attacks and defends.
Figure 3: Network architecture

Lai trains his network with a carefully generated set of data taken from real chess games. This data set must have the correct distribution of positions. “For example, it doesn’t make sense to train the system on positions with three queens per side, because those positions virtually never come up in actual games,” he says.

It must also have plenty of variety of unequal positions beyond those that usually occur in top level chess games. That’s because although unequal positions rarely arise in real chess games, they crop up all the time in the searches that the computer performs internally.

And this data set must be huge. The massive number of connections inside a neural network have to be fine-tuned during training and this can only be done with a vast dataset. Use a dataset that is too small and the network can settle into a state that fails to recognize the wide variety of patterns that occur in the real world.

Lai generated his dataset by randomly choosing five million positions from a database of computer chess games. He then created greater variety by adding a random legal move to each position before using it for training. In total he generated 175 million positions in this way.

The usual way of training these machines is to manually evaluate every position and use this information to teach the machine to recognize those that are strong and those that are weak.

But this is a huge task for 175 million positions. It could be done by another chess engine but Lai’s goal was more ambitious. He wanted the machine to learn itself.

Instead, he used a bootstrapping technique in which Giraffe played against itself with the goal of improving its prediction of its own evaluation of a future position. That works because there are fixed reference points that ultimately determine the value of a position—whether the game is later won, lost or drawn. 

In this way, the computer learns which positions are strong and which are weak.

Having trained Giraffe, the final step is to test it and here the results make for interesting reading. Lai tested his machine on a standard database called the Strategic Test Suite, which consists of 1,500 positions that are chosen to test an engine’s ability to recognize different strategic ideas. “For example, one theme tests the understanding of control of open files, another tests the understanding of how bishop and knight’s values change relative to each other in different situations, and yet another tests the understanding of center control,” he says.

The results of this test are scored out of 15,000.

Lai uses this to test the machine at various stages during its training. As the bootstrapping process begins, Giraffe quickly reaches a score of 6,000 and eventually peaks at 9,700 after only 72 hours. Lai says that matches the best chess engines in the world.
Figure 4: Training log
[That] is remarkable because their evaluation functions are all carefully hand-designed behemoths with hundreds of parameters that have been tuned both manually and automatically over several years, and many of them have been worked on by human grandmasters,” he adds.

Lai goes on to use the same kind of machine learning approach to determine the probability that a given move is likely to be worth pursuing. That’s important because it

  • prevents unnecessary searches down unprofitable branches of the tree and 
  • dramatically improves computational efficiency.
Lai says this probabilistic approach predicts the best move 46 percent of the time and places the best move in its top three ranking, 70 percent of the time. So the computer doesn’t have to bother with the other moves.

That’s interesting work that represents a major change in the way chess engines work. It is not perfect, of course. One disadvantage of Giraffe is that neural networks are much slower than other types of data processing. Lai says Giraffe takes about 10 times longer than a conventional chess engine to search the same number of positions.

But even with this disadvantage, it is competitive. “Giraffe is able to play at the level of an FIDE International Master on a modern mainstream PC,” says Lai. By comparison, the top engines play at super-Grandmaster level.

That’s still impressive. “Unlike most chess engines in existence today, Giraffe derives its playing strength not from being able to see very far ahead, but from being able to evaluate tricky positions accurately, and understanding complicated positional concepts that are intuitive to humans, but have been elusive to chess engines for a long time,” says Lai. “This is especially important in the opening and end game phases, where it plays exceptionally well.

And this is only the start. Lai says it should be straightforward to apply the same approach to other games. One that stands out is the traditional Chinese game of Go, where humans still hold an impressive advantage over their silicon competitors. Perhaps Lai could have a crack at that next.

Ref: arxiv.org/abs/1509.01549 : Giraffe: Using Deep Reinforcement Learning to Play Chess

lunes, 14 de septiembre de 2015

Designer molecule shines a spotlight on mysterious four-stranded DNA

Confocal microscopy image of the new molecule inside human bone cancer cells

A small fluorescent molecule has shed new light on knots of DNA thought to play a role in regulating how genes are switched on and off.

DNA is typically arranged in a double helix, where two strands are intertwined like a coiled ladder, but previous research has shown the existence of unusual DNA structures called quadruplexes, where four strands are arranged in the form of little knots.

Now researchers at Imperial College London led by Dr Marina Kuimova and Professor Ramon Vilar are unravelling the mysteries of these four-stranded DNA structures. They have created a fluorescent molecule that can reveal the presence of these structures in living cells.

This could be a game changer to accelerate research into these DNA structures.
– Professor Ramon Vilar

The team used the glowing molecule to target quadruplex DNA inside human bone cancer cells grown in the laboratory. Together with colleagues from Kings College London, they studied the interactions between the two in real time, using powerful microscopes. 

Quadruplexes can form when a strand of DNA rich in guanines – one of the four building blocks in DNA - folds over onto itself. Several distinct quadruplex structures have been found in the human genome but their exact role remains unclear. Recent studies have shown they are particularly prevalent in regions nearby oncogenes – genes that have the potential to cause cancer.
Structure of a G-quadruplex DNA
highlighting one of the guanine
tetrads
There is mounting evidence that quadruplexes are involved in switching genes on and off because of where they are usually positioned within the genome, says Professor Vilar, from Imperial's Department of Chemistry.

If this can be proved, it would make quadruplexes an extremely important target for treating diseases such as cancer. But to understand what role they play, we need to be able to study them in living cells. Our new fluorescent molecule allows us to do this by directly monitoring the behaviour of quadruplexes inside living cells in real time.

The team designed the fluorescent molecule to glow more intensely when attached to DNA. Using powerful microscopes they discovered that they could distinguish between the molecules binding to the more common double helical DNA and quadruplex DNA because it glowed for much longer when bound to quadruplexes.

HUNT FOR NEW COMPOUNDS
The researchers were also able to visualise the fluorescent molecule being displaced from quadruplex DNA by another molecule known to be a very good quadruplex binder. This suggests that the Imperial molecule could be used to hunt for new compounds that can bind to quadruplexes.

Co-author Arun Shivalingam, who worked on the study during his PhD at Imperial, says: “Until now, to image quadruplexes in cells researchers have had to hold the cells in place using chemical fixation. However, this kills them and brings into question whether the molecule really interacts with quadruplexes in a dynamic environment.

Professor Vilar adds: “We’ve shown that our molecule could be potentially used to verify in live cells and in real time whether potential quadruplex DNA binders are hitting their target. This could be a game changer to accelerate research into these DNA structures.

-
'The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy' (DOI: 10.1038/ncomms9178) is published in Nature Communications on 09 September 2015.

09 September 2015

viernes, 13 de septiembre de 2013

Marin Sawa: Algaerium Bioprinter prints healthy food in your home

ORIGINAL: This Is AliveMarin Sawa

Marin Sawa
The Algaerium Bioprinter’ prototype demonstrates how microalgae can be cultivated in our domestic space to provide digitally printed health food on demand. This project refers to my previous work, which explored the aesthetic and functions of microalgae living systems. Here, Algaerium acts as an ink reservoir, containing ‘superfood’ microalgae such as Chlorella, Spirulina and Haematococcus. The selection of the algae strains reflects the diversity of colours in algae and allows for colourful printed patterns. Often algaes’ colours also indicate their nutraceutical values. For instance, Chlorella is exploited as health food for its high content of chlorophylls, responsible for its green pigmentation. Such species are cultivated on industrial scale and are increasingly in demand in today’s global health food market.

The Bioprinter envisions an immediate future in which algae ‘farming’ forms a new part of urban agriculture to reinforce food safety in our cities.

My project aims at adapting this industrial-scale production to a domestic technology. For this, I have been working in collaboration with Imperial College London to develop a new inkjet printing technology suitable for algae printing. By introducing living microalgae to food printing, we have invented a new way of consuming health food supplements. At micro scale, the Bioprinter technology provides a process in which cells can be ruptured and their nutrients can be readily absorbed. At macro scale, the Bioprinter envisions an immediate future in which algae ‘farming’ forms a new part of urban agriculture to reinforce food safety in our cities. We are also currently developing the technology to print algal-based energy devices as well as filtering devices. This research is part of my doctoral research at Central Saint Martins College of Arts and Design in London in collaboration with Imperial College London.

Marin Sawa
Marin Sawa
Marin is a designer and PhD researcher, practising at the intersection of textile and architectural design with biotechnology. She is particularly interested in the synthesis of art, science and technology in the context of design and sustainability.

She previously studied at the Architectural Association for her BA (Hons), Architecture and RIBA part1. She spent several years in Tokyo working for various architects firms and charismatic designers, including Taisuke Higuchi (Mackintosh/Globe Trotter Marunouchi), the renowned architects office, Kengo Kuma and Associates (Tokyo Agricultural University Museum, Designers Mansions 'Ajito', exhibition designs, the web design for the Kengo Kuma office), which led her to explore her passion for material structures culminating in a master's degree at Central Saint Martins entitled Design For Textile Futures, from which she has graduated with distinction.

Recent awards include the 2012 UAL International Graduate Scholarship, for funding her research degree at CSM, and 2012 Color in Design Award sponsored by Pantone.

Currently, as of the duration of her PhD (2011/12-2015), she is the Artist in Residence at Biochemistry Dep. (The Nixon Group), Sir Ernst Chain Building – Wolfson Laboratories, Imperial College London. This unique collaboration has been forged through the Energy Futures Lab, Imperial College, based on the commonality, algae, between her best-known work, Algaerium and their algal research: she continues to explore an intersection of design and algal biotechnology for an urban environment.






lunes, 22 de julio de 2013

"Intelligent knife" tells surgeon if tissue is cancerous

17 July 2013




Scientists have developed an "intelligent knife" that can tell surgeons immediately whether the tissue they are cutting is cancerous or not.

In the first study to test the invention in the operating theatre, the iKnife” diagnosed tissue samples from 91 patients with 100 per cent accuracy, instantly providing information that normally takes up to half an hour to reveal using laboratory tests.

The findings, by researchers at Imperial College London, are published today in the journal Science Translational Medicine. The study was funded by the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, the European Research Council and the Hungarian National Office for Research and Technology.

In cancers involving solid tumours, removal of the cancer in surgery is generally the best hope for treatment. The surgeon normally takes out the tumour with a margin of healthy tissue. However, it is often impossible to tell by sight which tissue is cancerous. One in five breast cancer patients who have surgery require a second operation to fully remove the cancer. In cases of uncertainty, the removed tissue is sent to a lab for examination while the patient remains under general anaesthetic.

The iKnife is based on electrosurgery, a technology invented in the 1920s that is commonly used today. Electrosurgical knives use an electrical current to rapidly heat tissue, cutting through it while minimising blood loss. In doing so, they vaporise the tissue, creating smoke that is normally sucked away by extraction systems.
We believe it has the potential to reduce tumour recurrence rates and enable more patients to survive.
Dr Zoltan Takats

The inventor of the iKnife, Dr Zoltan Takats of Imperial College London, realised that this smoke would be a rich source of biological information. To create the iKnife, he connected an electrosurgical knife to a mass spectrometer, an analytical instrument used to identify what chemicals are present in a sample. Different types of cell produce thousands of metabolites in different concentrations, so the profile of chemicals in a biological sample can reveal information about the state of that tissue.

In the new study, the researchers first used the iKnife to analyse tissue samples collected from 302 surgery patients, recording the characteristics of thousands of cancerous and non-cancerous tissues, including brain, lung, breast, stomach, colon and liver tumours to create a reference library. The iKnife works by matching its readings during surgery to the reference library to determine what type of tissue is being cut, giving a result in less than three seconds.

The technology was then transferred to the operating theatre to perform real-time analysis during surgery. In all 91 tests, the tissue type identified by the iKnife matched the post-operative diagnosis based on traditional methods.

While the iKnife was being tested, surgeons were unable to see the results of its readings. The researchers hope to carry out a clinical trial to see whether giving surgeons access to the iKnife’s analysis can improve patients’ outcomes.

These results provide compelling evidence that the iKnife can be applied in a wide range of cancer surgery procedures,” Dr Takats said. “It provides a result almost instantly, allowing surgeons to carry out procedures with a level of accuracy that hasn’t been possible before. We believe it has the potential to reduce tumour recurrence rates and enable more patients to survive.

Although the current study focussed on cancer diagnosis, Dr Takats says the iKnife can identify many other features, such as tissue with an inadequate blood supply, or types of bacteria present in the tissue. He has also carried out experiments using it to distinguish horsemeat from beef.

Professor Jeremy Nicholson, Head of the Department of Surgery and Cancer at Imperial College London, who co-authored the study, said: “The iKnife is one manifestation of several advanced chemical profiling technologies developed in our labs that are contributing to surgical decision-making and real-time diagnostics. These methods are part of a new framework of patient journey optimisation that we are building at Imperial to help doctors diagnose disease, select the best treatments, and monitor individual patients’ progress as part our personalised healthcare plan.

Lord Darzi, Professor of Surgery at Imperial College London, who also co-authored the study, said: “In cancer surgery, you want to take out as little healthy tissue as possible, but you have to ensure that you remove all of the cancer. There is a real need for technology that can help the surgeon determine which tissue to cut out and which to leave in. This study shows that the iKnife has the potential to do this, and the impact on cancer surgery could be enormous.

Lord Howe, Health Minister, said: “We want to be among the best countries in the world at treating cancer and know that new technologies have the potential to save lives. The iKnife could reduce the need for people needing secondary operations for cancer and improve accuracy, and I’m delighted we could support the work of researchers at Imperial College London. This project shows once again how Government funding is putting the UK at the forefront of world-leading health research.
Reference

J. Balog et al. ‘Intraoperative tissue identification using rapid evaporative ionization mass spectrometry.’ Sci. Transl. Med. 5, 194ra93 (2013).