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When neurobiologist Bill Newsome got a phone call from Francis Collins in March, his first reaction was one of dismay. The director of the US National Institutes of Health had contacted him out of the blue to ask if he would co-chair a rapid planning effort for a ten-year assault on how the brain works. To Newsome, that sounded like the sort of thankless, amorphous and onerous task that would ruin a good summer. But after turning it over in his mind for 24 hours, his dismay gave way to enthusiasm. “The timing is right,” says Newsome, who is based at Stanford University School of Medicine in California. He accepted the task. “The brain is the intellectual excitement for the twenty-first century.
It helped that the request for the brain onslaught was actually coming from Collins's ultimate boss — US President Barack Obama. Just two weeks after that call, on 2 April, Obama announced a US$100-million initial investment to launch the BRAIN Initiative, a research effort expected to eventually cost perhaps ten times that amount. The European Commission has equal ambitions. On 28 January, it announced that it would launch the flagship Human Brain Project with a 2013 budget of €54 million (US$69 million), and contribute to its projected billion-euro funding over the next ten years (see Nature 482, 456458; 2012).
Although the aims of the two projects differ, both are, in effect, bold bids for the neuroscientist's ultimate challenge: to work out exactly how the billions of neurons and trillions of connections, or synapses, in the human brain organize themselves into working neural circuits that allow us to fall in love, go to war, solve mathematical theorems or write poetry. What's more, researchers want to understand the ways in which brain circuitry changes — through the constant growth and retreat of synapses — as life rolls by.
Reaching this goal will require innovative new technologies, ranging from nanotechnologies to genetics to optics, that can capture the electrical activity coursing through neurons, prod those neurons to find out what they do, map the underlying anatomical circuits in fine detail and process the exabytes of information all this work will spit out.Think about it,” says neuroscientist Konrad Kording of Northwestern University in Chicago, Illinois. “The human brain produces in 30 seconds as much data as the Hubble Space Telescope has produced in its lifetime.
Researchers are already chipping away at the problem: the past few years have seen startling advances in techniques that allow the stimulation of precise neurons deep in the brain using light, for example, and the construction of anatomical maps with unprecedented detail. So far, most neuroscientists are using simpler species such as mice or worms to learn basic principles that evolution may have conserved in humans. Here, Nature examines some of the technological advances that will be necessary to drive further, and faster, into the brain.

1) Measuring it

If researchers are to make sense of the frenzy of electrical signals coursing through the brain's circuits, they will need to record simultaneously from as many neurons as possible.